A grand church interior with high vaulted ceilings, large columns, and a central altar.

Santo Spirito Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to CA $4,200 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Santo Spirito Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • Jan 2 - Jan 9

    Hotel Villa Liana + Flight

    Historic Centre of Florence
    6 nights
    3.0 star property
    8.8/10 - Excellent (380 reviews)
    Roundtrip • Calgary (YYC) - Florence (FLR)
    YYC - FLR • 2 stops FLR - YYC • 2 stops
    CA $2,414
    CA $1,949
    per traveller
    found 1 day ago
    Hotel Villa Liana
  • Jan 2 - Jan 9

    Aurum Uffizi + Flight

    Historic Centre of Florence
    6 nights
    4.0 star property
    7.6/10 - Good (1,001 reviews)
    Roundtrip • Calgary (YYC) - Florence (FLR)
    YYC - FLR • 2 stops FLR - YYC • 2 stops
    CA $2,946
    CA $2,056
    per traveller
    found 1 day ago
    Aurum Uffizi
  • Jan 2 - Jan 9

    Hotel La Scaletta Al Ponte Vecchio + Flight

    Historic Centre of Florence
    6 nights
    4.0 star property
    9.0/10 - Wonderful (1,000 reviews)
    "Giovanni was so very helpful, as well as the rest of the staff. The hotel’s location is very nice. It’s close to the bridge, but in a section that’s not too terribly busy. The terrace upstairs was absolutely amazing, as well as the restaurant. I highly recommend this hotel"
    Reviewed November 8, 2026
    Roundtrip • Calgary (YYC) - Florence (FLR)
    YYC - FLR • 2 stops FLR - YYC • 2 stops
    CA $3,279
    CA $2,543
    per traveller
    found 1 day ago
    Hotel La Scaletta Al Ponte Vecchio
  • Jan 2 - Jan 9

    Dimora Palanca Boutique & SPA + Flight

    Historic Centre of Florence
    6 nights
    5.0 star property
    9.2/10 - Wonderful (80 reviews)
    "All"
    Reviewed October 31, 2026
    Roundtrip • Calgary (YYC) - Florence (FLR)
    YYC - FLR • 2 stops FLR - YYC • 2 stops
    CA $2,965
    CA $2,367
    per traveller
    found 1 day ago
    Dimora Palanca Boutique & SPA
  • Jan 2 - Jan 9

    Alfieri9 + Flight

    Historic Centre of Florence
    6 nights
    3.0 star property
    9.6/10 - Exceptional (176 reviews)
    "It was a great experience. Not far from the center but in a quieter neighborhood. Clean and well kept property."
    Reviewed November 7, 2026
    Roundtrip • Calgary (YYC) - Florence (FLR)
    YYC - FLR • 2 stops FLR - YYC • 2 stops
    CA $2,530
    CA $2,023
    per traveller
    found 1 day ago
    Alfieri9

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Learn more about Santo Spirito

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Florence.

Duomo

Piazza del Duomo and Piazza di Santa Maria Novella are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

Santa Croce

Travelers come to Santa Croce for its interesting museums, and you can see top attractions like Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Discover the most popular places to visit in Santo Spirito

What to do near Santo Spirito

Santo Spirito Hotel Deals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently Asked Questions

How much does a Santo Spirito vacation package cost?

From just CA $1,949. Yes, you read that right. Our Santo Spirito packages are the best way to make your dollar go further. Bundle your favorite hotels, flights and rental car and explore this wonderful destination.

How do I get a cheap travel package to Santo Spirito?

If you love scoring a bargain, bundle your bookings into a Santo Spirito vacation package. Whether you need hotels, flights, activities or rental cars, you can book everything in one place. You'll have endless choice at your fingertips as well. Expedia has more than 550 partner airlines and 1,000,000 hotels across the globe to choose from. Fly with who you want, stay in a place you like and save precious dollars — now that's the ideal getaway!

What are the top hotels in Santo Spirito?

Reserve a room at Sweet Home Campuccio, 2 Double Bedrooms In San Frediano. It's one of this area's most sought-after hotels. Another well-known option in Santo Spirito is Residenza Oltrarno, An Elegant Apartment In The Historic Center Of Florence.

How far in advance should I book my Santo Spirito vacation?

To score cheap prices, book as soon as you can. Airlines typically release tickets, along with some of the lowest fares, up to a year in advance. Hotels, activities and car rental should also be booked early to avoid disappointment. If you were hoping for a last-minute getaway in Santo Spirito, there are always lots of great deals on Expedia. Check them out now!

What does an Expedia Santo Spirito travel package include?

Rental cars, flights and hotels, or any combination of the three — it's totally up to you. Whether you're headed to Santo Spirito with the entire family or enjoying a solo break, there's a bundle to match every budget and style. Once you've made your booking, why not add on a couple of tours as well?

What should I know before booking a Santo Spirito travel package?

Locking in all the parts of your trip together is one of the best ways to save. Combine car rentals, airfares and hotels into a neat little package. But you're not restricted to hotels. Expedia features all sorts of properties, including vacation rentals like oceanfront condos and city residences. The list goes on!

Can I choose my airline with a Santo Spirito Expedia vacation package?

Yes — and it's simple too. Expedia has access to more than 550 partner airlines all over the world. Our vacation packages give you the freedom to pick from available flights, hotels and activities that suit you.

If I'm not able to travel, can I cancel my Santo Spirito vacation package?

If your vacation plans in Santo Spirito have been upended, it's a relief to know that it is possible to cancel your booking. If you made your booking within the last 24 hours, you may be eligible for a refund. If your booking is older than that, your airline, hotel or car rental company may charge a fee. For more details, check our Customer Service Portal.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.